Δ^<4,6>-3-ケトステロイドと硫化水素との反応
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概要
- 論文の詳細を見る
Transannular reaction of 6-dehydro-17α-methyltestosterone (I) and/or 4,6-androstadiene-3,17-dione (V) with hydrogen sulfide, in the presence of sodium methoxide, mainly afforded the corresponding 5α, 7α-disulfide, II and VI, respectively. Selective reduction of VI with sodium borohydride at room temperature below 30° yielded a mixture of 5α, 7α-epidithioandrostane-3α, 17β-diol (VIII) and its 3β isomer (IX). Further treatment of sodium borohydride at 60° converted dioldisulfides (VIII and IX) to diol-dithiols, which were isolated as tetraacetates (XIV and XV, respectively).
- 公益社団法人日本薬学会の論文
- 1971-12-25
著者
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金子 秀彦
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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金子 秀彦
大日本製薬株式会社中央研究所
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大和 譲
大日本製薬株式会社総合研究所
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黒川 美貴雄
大日本製薬株式会社総合研究所
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黒川 美貴雄
大日本製薬株式会社創薬研究所
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