Syntheses of 6,6a, 7,8,9,10,10a, 11-Octahydro-11-oxodibenz [b, e] oxepins and 6,6a, 7,8,9,10,10a, 11-Octahydro-11-oxodibenzo [b, e] thiepins

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概要

• 論文の詳細を見る

• Two new partially saturated tricyclic ring systems, 6,6a, 7,8,9,10,10a, 11-octahydro-11-oxodibenz [b, e] oxepins (3a and 3b), and -thiepins (4a and 4b) were synthesized. Compounds 4a and 4b were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10b). Deuterated 4a and 4b (11a and 11b) were prepared starting from butadiene-d_6 (12). The stereochemical features of 3a (trans), 3b (cis), 4a (trans) and 4b (cis) are compared with those of 10a, 10b, 11a and 11b on the basis of proton nuclear magnetic resonance data.

• 公益社団法人日本薬学会の論文
• 1983-12-25

著者

• 永井 保嵩

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 宇野 準

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,

• 宇野 準

  大日本製薬株式会社総合研究所

• 吉田 耕治

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 黒川 美貴雄

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

• 宇野 準

  大日本製薬株式会社

• 宇野 準

  大日本製薬

• 宇野 準

  Research Laboratory Dainippon Pharmaceutical Co. Ltd.

• 黒川 美貴雄

  大日本製薬株式会社創薬研究所

• 宇野 準

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

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