Studies on Psychotropic Agents. III. Synthesis of 1-Substituted 2-[2-(p-Fluorobenzoyl) ethyl] piperidines and Related Compounds
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概要
- 論文の詳細を見る
A series of 1-substituted piperidine and 1,2,3,6-tetrahydropyridine derivatives bearing an aroylethyl group in the 2-position or a p-pluorobenzoyl group in the 4-position were synthesized for pharmacological testing. 1-Ethyl-2-[2-(p-fluorobenzoyl) ethyl] piperidine (6e) exhibited the most potent neuroleptic activity and its pharmacological profile is similar to that of thioridazine (I). Among the butyrophenone derivatives containing their side chain in the piperidine ring, 1-ethyl-3-(p-fluorophenacyl) piperidine (III) showed the most potent activity.
- 公益社団法人日本薬学会の論文
- 1979-05-25
著者
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永井 保嵩
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宇野 準
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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宇野 準
大日本製薬株式会社
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梅本 進
Research Laboratory, Dainippon Pharmaceutical Co., Ltd.
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梅本 進
Research Laboratory Dainippon Pharmaceutical Co. Ltd.
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宇野 準
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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