Synthesis and Spasmolytic Activity of 2-Substituted-3-(ω-dialkylaminoalkoxyphenyl) acrylonitriles and Related Compounds
スポンサーリンク
概要
- 論文の詳細を見る
Several analogs of (Z)-2-(1,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]-acrylonitrile (1a), such as (Z)-2-(1,2-benzisothiazol-3-yl)-, (Z)-2-(1H-indol-3-yl)-, (E)-2-(2-thienyl)-and (E)-2-benzoyl-3-(ω-dialkylaminoalkoxyphenyl) acrylonitriles (2-5), were synthesized by means of the Knoevenagel condensation. The descyano analog (6) was prepared by means of the Wittig reaction. Triethylammonium formate reduction of 1 afforded the dihydro analog (7). The spasmolytic activities of these analogs were examined. Among these compounds, (Z)-2-(1,2-benzisothiazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]-acrylonitrile (2a) and (Z)-2-(1,2-benzisothiazol-3-yl)-3-[2-(2-morpholinoethoxy) phenyl]-acrylonitrile (2b) showed potent antispasmodic activities in vitro and in vivo (in mice).
- 公益社団法人日本薬学会の論文
- 1983-06-25
著者
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門河 敏明
大日本製薬株式会社総合研究所
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西村 温樹
Research Laboratories:dainippon Pharmaceutical Co. Ltd.
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西村 温樹
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宇野 準
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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成戸 俊介
Research Laboratories Dainippon Pharmaceutical Co. Ltd
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成戸 俊介
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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水田 泰之
Research Laboratories, Dainippon Pharmaceutical Co., Ltd,
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宇野 準
大日本製薬株式会社総合研究所
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水田 泰之
Research Laboratories Damippon Pharmaceutical Co. Ltd.
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吉田 豊吉
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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河島 勝良
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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宇野 準
大日本製薬株式会社
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宇野 準
大日本製薬
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宇野 準
Research Laboratory Dainippon Pharmaceutical Co. Ltd.
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門河 敏明
Research Laboratories, Damippon Pharmaceutical Co., Ltd.
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河島 勝良
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宇野 準
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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門河 敏明
Research Laboratories Damippon Pharmaceutical Co. Ltd.
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吉田 豊吉
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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