Acrylamide Derivatives as Antiallergic Agents.III. : Synthesis and Structure-Activity Relationships of N-[4-(4-Diphenylmethyl-1-piperazinyl)butyl]- and N-[4-(4-Diphenylmethylene-1-piperidyl)butyl]-3-heteroarylacrylamides

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概要

• 論文の詳細を見る

• A new series of 3-heteroarylacrylamides 2 and 4 was prepared and the inhibitory activities against the rat passive cutaneous anaphylaxis (PCA) reaction and the enzyme 5-lipoxygenase (5-LO) were tested. Most of the compounds exhibited an anti-PCA activity superior to or equivalent to ketotifen and had a 5-LO inhibitory activity. The 3-heteroarylacrylamide derivatives including 3-(3-pyridyl)acrylamides represent a new structural class of compound that exhibits not only an in vivo anti-PCA activity but also an in vitro 5-LO ingibitory activity.

• 公益社団法人日本薬学会の論文
• 1989-03-25

著者

• 中村 秀雄

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 宇野 準

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,

• 石井 勝美

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 西川 義則

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,

• 新藤 徳彦

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,

• 近 達也

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,

• 宇野 準

  大日本製薬株式会社

• 近 達也

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 宇野 準

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 西川 義則

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 新藤 徳彦

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

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