非ステロイド性鎮痛・抗炎症薬Tolmetin Sodiumの関節炎痛, 打撲浮腫ならびにLPS発熱に対する影響

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Anti-inflammatory, analgesic and anti-pyretic activities of tolmetin sodium were studied in comparison with aspirin, ibuprofen and indomethacin. Analgesic ED_<50> value of tolmetin sodium against AgNO_3-induced arthritic pain in rats was 27.2mg/kg, p.o. and the potency was about 20 times, twice and 3 times that of aspirin, ibuprofen and mefenamic acid, respectively, and about 1/3 and 1/13 times that of diclofenac sodium and indomethacin, respectively. Tolmetin sodium showed a significant therapeutic effect on traumatic hind paw edema in rats at a dose of 20mg/kg, p.o. or more, and the potency was 4 times or more that of aspirin, about the same as ibuprofen and about 1/10 times that of indomethacin. The anti-pyretic ED_<50> value of tolmetic sodium in adjuvantinduced febrile rats was 15.8mg/kg, p.o., and the potency was about 2.5 times that of aspirin and about 1/13 and 1/40 times that of ibuprofen and indomethacin, respectively. Tolmetin sodium showed an anti-pyretic effect on lipopolysaccharide-induced fever in rabbits at a dose of 40 mg/kg, p.o. or more, and the potency was about 3 times that of aspirin, about the same as ibuprofen and about 1/10 times that of indomethacin. These results confirm the previous results that tolmetin sodium has possessed a relatively potent inhibitory activity on inflammatory pain and acute inflammation.
社団法人日本薬学会の論文
1981-07-25