Studies on 3-Substituted 1,2-Benzisoxazole Derivatives. II. The Catalytic Reductions of 1,2-Benzisoxazole-3-acetamide Oxime and Related Compounds
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概要
- 論文の詳細を見る
The hydrogenation of 1,2-benzisoxazole-3-acetamide oxime (1) proceeded as follows. At first 1 absorbed one molar hydrogen to give 2-hydroxybenzimidoylacetamide oxime (2) and then 2 was cyclized to 3-amino-5-(2-hydroxyphenyl) isoxazole (4) which absorbed one more molar hydrogen to give 2-hydroxybenzoylacetamidine (3). The alkaline treatment of 2-hydroxybenzoylacetonitrile (11), which was obtained from 1,2-benzisoxazole-3-acetnitrile (9) by the catalytic reduction and successive hydrolysis, gave 2-coumarinimine (12). The acidic treatment of 2-hydroxybenzimidoylacetamide (13), which was the product of the catalytic reduction of 1,2-benzisoxazole-3-acetamide (8), afforded 4-aminocoumarin (15), an isomer of 12.
- 公益社団法人日本薬学会の論文
- 1976-04-25
著者
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西村 温樹
Research Laboratories:dainippon Pharmaceutical Co. Ltd.
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西村 温樹
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宇野 準
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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宇野 準
大日本製薬株式会社総合研究所
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黒川 美貴雄
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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宇野 準
大日本製薬株式会社
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黒川 美貴雄
大日本製薬株式会社創薬研究所
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宇野 準
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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