Synthesis of 1-((S)-3-Acetylthio-2-methylpropanoyl)-L-propyl-L-Phenylalanine (Alacepril) and One of Its Active Metabolites, the Desacetyl Derivative : DU-1227
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概要
- 論文の詳細を見る
The synthesis of 1-((S)-3-acetylthio-2-methylpropanoyl)-L-prolyl-L-phenylalanine 1 (alacepril, code name : DU-1219), a clinically used antihypertensive agent, and one of its active metabolites, 1-((S)-3-mercapto-2-methylpropanoyl)-L-prolyl-L-phenylalanine 2 (code name : DU-1227), is described. The application of chloral to the N-formylation of L-proline is also described. The presence of an intramolecular hydrogen bond in the trans conformer of 1 in solution is suggested on the basis of spectroscopic examinations of 1 and its ethyl ester 4.
- 公益社団法人日本薬学会の論文
- 1990-02-25
著者
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澤山 忠弘
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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西村 温樹
Research Laboratories:dainippon Pharmaceutical Co. Ltd.
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西村 温樹
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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木村 嘉孝
Department Of Chemical Technology:dainippon Pharmaceutical Co. Ltd.
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糸川 彰
Research Laboratories
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嶋田 莞爾
Department of Chemical Technology
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土居 康正
Department of Chemical Technology
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糸川 彰
Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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澤山 忠弘
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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糸川 彰
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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嶋田 莞爾
Department Of Chemical Technology:dainippon Pharmaceutical Co. Ltd.
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土居 康正
Department Of Chemical Technology:dainippon Pharmaceutical Co. Ltd.
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