Mannich Reaction of Dihydropyridine Derivatives. I. Reactions with Secondary Amines
スポンサーリンク
概要
- 論文の詳細を見る
Dialkyl 4-aryl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates (III) were subjected to the Mannich reaction with excess paraformaldehyde and secondary amine hydrochloride in boiling ethanolic solution. When the compounds III were treated with a 5-to 7-fold molar excess of the aldehyde and amine salt, 2,6-bis (2-disubstituted aminoethyl)-dihydropyridine derivatives (V) were obtained in good yields. On treatment with a 2- to 3-fold molar excess of the reactants, compounds III were converted to 2-(2-disubstituted aminoethyl)-6-methyldihydropyridine derivatives (IV) and V. When dioxane was used as a solvent with a 6-fold molar excess of the reactants, the tetrakis (dimethylaminomethyl) derivative (VII) was obtained.
- 公益社団法人日本薬学会の論文
- 1980-11-25
著者
-
西村 温樹
Research Laboratories:dainippon Pharmaceutical Co. Ltd.
-
西村 温樹
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
-
有富 治郎
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
-
上田 昇三
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
-
上田 昇三
Research Laboratories Damippon Pharmaceutical Co. Ltd.
-
有富 治郎
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
関連論文
- Smiles Rearrangement in Isoquinolinium Salts(Organic,Chemical)
- Yokonosideおよびその関連化合物の合成
- Corydalis属植物の成分研究(第12報) Dihydroprotoberberine型エナミンとホルムアルデヒドとの反応
- Isolation of a New Isoflavone from Chinese Pueraria Flowers
- 8,13a-Propanoberbines. V. Michael Type Condensation of Acetoneberberine Type Enamine
- 8,13a-Propanoberbines. IV. Potassium Permanganate Oxidation of Acetoneberberine Type Enamine
- 8,13a-Propanoberbines. III. Reaction of Acetoneberberine Type Enamine with Alkyl Halide
- 42 8,13a-プロパノベルビン誘導体の反応
- 4-Hydroxy-2(1H)-quinolone誘導体の合成
- 桃仁の研究(第3報)桃仁の抗炎症性蛋白成分PR-Bの抗活性酸素作用
- 桃仁の研究(第2報)桃仁の水抽出成分の薬理作用
- Preparation and Characterization of Hetero-bifunctional Cross-linking Reagents for Protein Modifications
- Studies on Phenylalkanethiolamine. VI. Synthesis and Configuration of 2-Phenyl-3,4-dimethylthiomorpholine
- Halogenations of S-Benzyl-S-phenylsulfoximides and Base-induced Rearrangements of Their N- and α-Halo Derivatives to N-Sulfinylimines
- Novel Base-Induced Rearrangements of α- and N-Halo Derivatives of S-Ary-S-[(1,2-benzisoxazol-3-yl) methyl] sulfoximides to the Corresponding N-Sulfinylimines
- Halogenation Reaction of S-Aryl-S-[(1,2-benzisoxazol-3-yl) methyl] sulfoximide
- Mannich Reaction of 1,4-Dihydroquinoline Derivatives
- Mannich Reaction of Dihydropyridine Derivatives. II. Reaction with Primary Amines
- Mannich Reaction of Dihydropyridine Derivatives. I. Reactions with Secondary Amines
- Studies on 3-Substituted 1,2-Benzisoxazole Derivatives. II. The Catalytic Reductions of 1,2-Benzisoxazole-3-acetamide Oxime and Related Compounds
- Studies on 3-Substituted 1,2-Benzisoxazole Derivatives. I
- Syntheses of New Thiamine Derivatives
- Composition and Structure of 2-Methylpiperazine-Carbon Disulfide Complex
- Synthesis of 1-((S)-3-Acetylthio-2-methylpropanoyl)-L-propyl-L-Phenylalanine (Alacepril) and One of Its Active Metabolites, the Desacetyl Derivative : DU-1227
- Synthesis and Spasmolytic Activity of Aminoalkyl 2-Substituted-2-(1,2-benzisoxazol-3-yl)acetates(Medicinal Chemistry,Chemical)
- Synthesis and Spasmolytic Activity of 2-Substituted-3-(ω-dialkylaminoalkoxyphenyl) acrylonitriles and Related Compounds
- The Structures of Isatylidene-3-mercaptoacetic Acid and Its Related Compounds
- Syntheses of Ornithine Decarboxylase Inhibitors : D-and DL-α-Hydrazinoornithine
- 第3回メディシナルケミストリーシンポジウム