42 8,13a-プロパノベルビン誘導体の反応
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概要
- 論文の詳細を見る
Acetoneberberine type enamine (2) gave 8,13a-propanoberbine derivatives on the following three reactions; a) oxidation of (2) with potassium permanganate, b) annelation via (2) as intermediate on the treatment of protoberberine type alkaloids with acetone in the presence of alkali, and c) alkylation of (2) with alkyl halide. The structures of 8,13a-propanoberbine derivatives were deduced from chemical and spectral data. Acidic hydrolysis of 8,13a-propanoberbine derivatives, Hofmann degradation product (24), and possible mechanism for this intramolecular cyclization of acetonyl group of (2) are discussed. The analysis of mass spectra of 8,13a-propanoberbine derivatives leading to find a characteristic fragmentation pattern is also discussed.
- 天然有機化合物討論会の論文
- 1972-10-01
著者
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金子 秀彦
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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金子 秀彦
大日本製薬株式会社中央研究所
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成戸 俊介
大日本製薬株式会社中央研究所
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西村 温樹
Research Laboratories:dainippon Pharmaceutical Co. Ltd.
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成戸 俊介
Research Laboratories Dainippon Pharmaceutical Co. Ltd
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成戸 俊介
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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西村 温樹
大日本製薬株式会社総合研究所
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成戸 俊介
大日本製薬(株)探索研究所
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