Oxidative Addition of Alkyl Mercaptans to Steroidal Δ^<4,6>-3-Ketones
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概要
- 論文の詳細を見る
Addition of ethyl mercaptan to 6-dehydro-17α-methyltestosterone (I) in the presence of the organic bases afforded two oxidative addition products together with the corresponding 7α-ethylthio derivative (II) in minor yields. Both of them were formulated as 6α-hydroxy-7β-ethylthio- and 6β-hydroxy-7α-ethylthio-17α-methyltestosterone (III and IV) by chemical evidences and the spectral data. Under similar condition, androsta-4,6-diene-3,17-dione (XII) gave an unexpected compound, 4-ethylthio-7β-hydroxyandrost-4-en-3-one (XXIII) accompanied with 7α-ethylthio (XIII), 6α-hydroxy-7β-ethylthio (XIV) and 6β-hydroxy-7α-ethylthio derivative (XV).
- 公益社団法人日本薬学会の論文
- 1970-09-25
著者
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金子 秀彦
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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黒川 美貴雄
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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黒川 美貴雄
大日本製薬株式会社総合研究所
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大和 讓
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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大和 讓
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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