Studies on Psychotropic Agents. V. Synthesis of 1-Substituted Spiro [dibenz [b, f] oxepin-11,4'-piperidine]-10 (11H)-one and Related Compounds
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概要
- 論文の詳細を見る
Tricyclic compounds (12,17 and 20) combined with a spiro-system at the 4 position of 1-substituted piperidine were synthesized for pharmacological testing. They could be prepared by a sequence of reactions involving the Pinacol rearrangement of 9-(1-ethoxy-carbonyl-4-piperidinyl) fluorene-9,4'-diol (9) or the cyclization of 1-benzyl-4-(o-substituted phenyl)-4-carboxy (or cyano) piperidine (15a and 16). 9-(1-Methyl-1,2,3,6-tetrahydro-4-pyridinyl) xanthene (or -anthracene) (21 and 26) and 3-methyl-2,3,4,5-tetrahydro-1H-phenanthro [9,10-d] azepine (27) were also prepared by the Wagner-Meerwein rearrangement of α hydroxy spiro compounds (19b, 19d, and 11,respectively). Among the compounds synthesized, 1-methyl-1,2,3,5,6,7-hexahydrospiro [[4H] azepine-4,9'-fluorene]-5-ol (8) showed marked anti-convulsant activity.
- 公益社団法人日本薬学会の論文
- 1979-09-25
著者
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永井 保嵩
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宇野 準
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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宇野 準
大日本製薬株式会社
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宇野 準
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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