Metabolism of Piromidic Acid, a New Antibacterial Agent. IV. Pharmacokinetics of Piromidic Acid in Rats
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概要
- 論文の詳細を見る
The pharmacokinetic studies of piromidic acid (PA, 5,8-dihydro-8-ethyl-5-oxo-2-pyrrolidinopyrido [2,3-d] pyrimidine-6-carboxylic acid) were performed in rats after intravenous administration. Two compartment model, the central and peripheral compartment was adopted and the central compartment was connected to four metabolite compartments in branched metabolic pathways, totaling eleven parameters involved. Each parameter was determined by conjunction of graphical and mathematical methods using the experimental data on blood levels along with urinary and biliary excretions in rats receiving PA or each metabolite. Calculated blood levels of PA or its metabolites thus obtained were found to be reasonable. The peripheral compartment is ascribed to enterohepatic circulation of PA. This pharmacokinetic model may possibly applied on human subjects, since urinary metabolic patterns were similar in rats and human subjects receiving PA.
- 公益社団法人日本薬学会の論文
- 1976-07-25
著者
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橋本 昌久
大日本製薬株式会社総合研究所
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橋本 昌久
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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中村 清
Research And Development Division Dainippon Pharmaceutical Co. Ltd.
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橋本 昌久
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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関根 豊
Research and Development Division, Dainippon Pharmaceutical Co., Ltd.
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宮本 美枝
Research and Development Division, Dainippon Pharmaceutical Co., Ltd.
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関根 豊
Department of Drug Metabolism, Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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関根 豊
Department Of Drug Metabolism Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宮本 美枝
Research And Development Division Dainippon Pharmaceutical Co. Ltd.
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