Uptake by Brain and Distribution of Radioactivity after Intravenous Administration of ^<14>C-Labelled Meclofenoxate in Mice

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The distribution of radioactivity after intravenous administration of MF-PCPA^*, MF-DMAE^*, PCPA^*, and DMAE^* was investigated by autoradiography and radioactivity measurement. The uptake of the label by brain was emphasized. Radioactivity was high in brain immediately after the injection of either MF-PCPA^* or MF-DMAE^*, but was negligible after the administration of the constituents. Radioactivity in brain remained relatively high even at 24 hr after administration of MF-DMAE^* while it was gradually disappeared after the injection of MF-PCPA^*. The distribution pattern of the label in whole body was very similar each other when animals were given MF-PCPA^* and PCPA^*, or when given MF-DMAE^* and DMAE^* except for the rapid condensation of the labelled MF into the brain.
公益社団法人日本薬学会の論文
1971-08-25