ウナギにおけるピロミド酸および代謝物の組織内濃度

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Levels of an antibacterial agent, piromidic acid (PA), and its metabolites (2-OHPA and 3-OHPA) in eel tissues after oral administration were determined by high-performance liquid chromatography, and following results were obtained. 1) After single administration of 40mg/kg of PA, both the unchanged drug and metabolites were found in plasma, liver, kidney spleen, and muscle with the order of PA, 2-OHPA, and 3-OHPA. The concentration of PA in tissues reached peak levels of 12-18 μg/ml or g 3-6 hours after dosing, followed by a gradual decrease with half-lives of 4-7 hours and went below the assay limit (0.02 μg/ml or g) in 4 days. Whereas the concentration of the metabolites reached peak levels of 4.1-9.1 μg/ml or g for 2-OHPA and 1.4-4.7 μg/ml or g for 3-OHPA 6-24 hours after dosing, followed by a relatively slow decrease with half-lives of 8-18 hours. Total levels of PA and metabolites in kidney and liver were one and a half times as high as the level in plasma, while the level in muscle was one half of that in plasma. 2) After 7-consecutive dosing of 40mg/kg per day of PA, the concentration of the unchanged drug and metabolites reached peak levels of 8.8-16 μg/ml or g for PA, 7.1-12 μg/ml or g for 2-OHPA, and 5.5-7.6 μg/ml or g for 3-OHPA, mostly 6 hours after the final dosing and total levels went below the assay limit within 11 days. 3) In the case of the treament of fish diseases with PA, PA and the metabolites would be eliminated from tissues within 6 days after single administration or 11 days after 7-consecutive administration.
日本水産學會の論文

ウナギにおけるピロミド酸および代謝物の組織内濃度

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