Pyridonecarboxylic Acids as Antibacterial Agents. VIII. An Alternative Synthesis of Enoxacin via Fhioronicotinic Acid Derivatives(Organic,Chemical)

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概要

• 論文の詳細を見る

• An alternative synthesis of enoxacin, a 1,8-naphthyridine antibacterial agent, was developed. The present method involves 1,8-naphthyridine ring construction by the Dieckmann type cyclization of ethyl 5-ffuoronicotinate having a 2-ethoxycarbonylethylainino moiety at C-2. This nicotinate was prepared in 7 steps from ethyl fluoroacetate via ethyl 2,6-dichloro-5-fluoronicotinate.

• 公益社団法人日本薬学会の論文
• 1987-06-25

著者

• 松本 純一

  Exploratory Research Laboratories Dainippon Pharmaceutical Company Ltd.

• 松本 純一

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 江川 宏

  Exploratory Research Laboratories, Dainippon Pharmaceutical Company, Ltd.,

• 宮本 皓之

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

• 江川 宏

  Research Laboratories Dainippon Pharmaceutical Co., Ltd.,

• 江川 宏

  Exploratory Research Laboratories Dainippon Pharmaceutical Company Ltd.

• 宮本 皓之

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

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