Inhibitory Effects of 3,3', 4,5'-Tetrahydroxystilbene and 3,3', 4,5'-Tetrahydroxybibenzyl, the Constituents of Cassia garrettiana on Antigen-Induced Histamine Release in Vitro

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概要

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• 3,3', 4,5'-Tetrahydroxystilbene (I) and 3,3', 4,5'-tetrahydroxybibenzyl (II), isolated from the heartwood of Cassia garrettiana CRAIB (Leguminosae), showed inhibitory effects on antigen-induced histamine release from rat peritoneal mast cells in vitro. The inhibitory effect of I (IC_<50>=30.2 μM) was much stronger than that of II (>100 μM). Compound II, as well as I (IC_<50>=7.3 μM) reported previously, also inhibited the histamine release from human peripheral basophils induced by anti-immunoglobulin E (IgE) in vitro, and its IC_<50>-value was 68.0 μM. These results suggest that the trans-olefin structure in the molecule may be necessary for I to have an inhibitory effect on histamine release. Considering that disodium cromoglycate did not show any significant inhibitory effect on anti-IgE-induced histamine release from human basophils, the strong inhibitory effects of I in both tests are of considerable interest.

• 社団法人日本薬学会の論文
• 1991-12-25

著者

• 小澤 貢

  大阪薬大

• 稲森 善彦

  Osaka University of Pharmaceutical Sciences

• 馬場 きみ江

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  Osaka University of Pharmaceutical Sciences

• 小澤 貢

  Osaka University of Pharmaceutical Sciences

• 小川 雅史

  Osaka University Of Pharmaceutical Sciences

• 中村 秀雄

  Dainippon Pharmaceutical Co., Ltd.,

• 辻坊 裕

  大阪薬大

• 中村 秀雄

  Dainippon Pharmaceutical Co. Ltd.

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