超臨界流体抽出の生薬, 植物成分への応用(第1報)蛇床子成分の抽出に及ぼす圧力, 温度, 時間, エントレーナーの影響

概要

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The supercritical fluid extraction was applied to the components of Cnidium formosanum fruits by use of carbon dioxide gas, and the effects of temperature, pressure and time on the extraction were examined to establish the way of applying this new technique to crude drugs. The optimum temperature and pressure for the extraction of furocoumarins such as columbianadin, bergapten, O-acetylcolumbianetin, edultin and columbianetin, with supercritical carbon dioxide were 40℃ and 400 bar, respectively. Although the amounts of extractives increased with prolonging extraction times, the increments after 80 min were small. Effects of entrainers were examined, and compared with those of the ordinary liquid extraction.
公益社団法人日本薬学会の論文
1987-05-25