The Biological Activities of 3,4-O-Isopropylidene-3,3'4,5'-tetrahydroxystilbene

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概要

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• A new compound, 3,4-O-isopropylidene-3,3', 4,5'-tetrahydroxystilbene (I), chemically derived from 3,3', 4,5'-tetrahydroxystilbene (II) showed strong antifungal activity, ichthyotoxicity, coronary vasodilator action on the isolated guinea-pig heart and a hypotensive effect on rats. These activities of I were much stronger than those of the original substance (II). As regards antifungal activity, the minimal growth inhibitory concentrations (MIC) of I for Trichophyton mentagrophytes and Fusarium oxysporum f. sp. lycopersici were 6 and 1μg/ml, respectively. As regards ichthyotoxic activity, the median tolerance limit (TLm) at 48 h was 14.0 ppm in Oryzias latipes TEMMINCK et SCHLEGEL. Compound (I) also had strong coronary vasodilator action on guinea-pig heart in vitro ; the ED_<50> value was 4.5μg/heart. Finally, I showed a strong hypotensive effect on rats (-43.0±5.2mmHg, 10mg/kg i.v.).

• 公益社団法人日本薬学会の論文
• 1985-07-25

著者

• 小澤 貢

  大阪薬大

• 稲森 善彦

  Osaka University of Pharmaceutical Sciences

• 馬場 きみ江

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  Osaka University of Pharmaceutical Sciences

• 小澤 貢

  Osaka University of Pharmaceutical Sciences

• 加藤 喜昭

  Osaka University Of Pharmaceutical Sciences

• 久保 真百合

  Osaka University of Pharmaceutical Sciences

• 安田 正秀

  大阪薬科大学

• 辻坊 裕

  大阪薬大

• 安田 正秀

  Osaka College of Pharmacy

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