Hypotensive Effects on Spontaneously Hypertensive Rats and Antifungal Activity on Various Species of Fusarium oxysporum of Diethylstilbestrol-Related Compounds

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概要

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• The diethylstilbestrol-related compounds 3,3'-dihydroxy-α, β-diethyldiphenylethane (I), diethylstibestrol (II) and hexestrol (III) showed hypotensive effects on spontaneously hypertensive rats (SHR) and antifungal activities against all Fusarium oxysporum sp. tested. As previously reported, I had strong hypotensive action on normotensive rats at the dose of 10 mg/kg, while II and III showed weak hypotensive effects on these rats at the same dose. In this work, all three compounds also had hypotensive actions on SHR at the same dose. I showed the strongest hypotensive effect (-80.0±5.0 mmHg, 10 mg/kg, i.v.) on both SHR and normotensive rats. The three compounds also had antifungal activities against five kinds of Fusarium oxysporum sp. tested. Especially, II strongly inhibited the growth of Fusarium oxysporum f. sp. raphani IFO-9972 (minimum inhibitory concentration (MIC) : 1.0 μg/ml).

• 社団法人日本薬学会の論文
• 1990-07-25

著者

• 山口 智美

  Osaka University Of Pharmaceutical Sciences

• 竹村 庄司

  Faculty Of Pharmaceutical Sciences Kinki University

• 稲森 善彦

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  Osaka University of Pharmaceutical Sciences

• 小川 雅史

  Osaka University Of Pharmaceutical Sciences

• 網野 比佐子

  Osaka University of Pharmaceutical Sciences

• 坪井 万里子

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  大阪薬大

• 竹村 庄司

  Faculty Of Pharmacy Kinki University

• 竹村 庄司

  近畿大薬

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