Effects of 3,3'-dihydroxy-α, β-diethylstilbene and 3,3', 4,5'-Tetrahydroxystilbene on Microtubule Assembly in Vitro, Aneuploidy Induction, and Cellular Microtubule and Actin Networks

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概要

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• We examined the inhibitory activities of 3,3'-dihydroxy-α, β-diethylstilbene (DDS) and 3,3', 4,5'-tetrahydroxystilbene (THS) on microtubule assembly in vitro and their effects on chromosome number and cellular microtubule networks in Chinese hamster V79 cells. DDS showed half the inhibitory activity of diethylstilbestrol (DES) on microtubule assembly in vitro, while THS had none of the inhibitory activity. DDS induced tetraploid at 30 μM, whereas THS was found to be inactive. Furthermore, DDS disturbed cellular microtubule networks at 100 μM.We also examined the effects of DES, DDS and THS on cellular actin networks in mouse BALB 3T3 cells. DES induced a change of actin stress fiber distribution and THS had similar activity, while DDS showed no activity.

• 社団法人日本薬学会の論文
• 1992-08-25

著者

• 佐藤 美洋

  北海道大学大学院薬学研究院

• 稲森 善彦

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  Osaka University of Pharmaceutical Sciences

• 佐藤 良博

  共立薬科大学名誉

• 小田 泰子

  Kyoritsu College of Pharmacy

• 榊原 由美子

  Kyoritsu College of Pharmacy

• 佐藤 良博

  Kyoritsu College of Pharmacy

• Sato Y

  Osaka Prefecture University

• Sato Y

  (present Address)tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• 辻坊 裕

  大阪薬大

• 斉藤 泉

  Kyoritsu College of Pharmacy

• 佐藤 嘉信

  Department Of Chemical Engineering University Of Osaka Prefecture

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