Synthesis and Antiviral Activity of Carbocyclic Oxetanocin Analogues(C-OXT-A, C-OXT-G) and Related Compounds. II

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概要

• 論文の詳細を見る

• 9-(cis-3-Hydroxymethyl-2-methylenecyclobutyl)guanine (3b) and 9-(3-methylene-trans-2-hydroxymethylcyclobuty)guanine (4b) were prepared from N^2-isobutyryl-9-[trans-trans-2,3-bis(hydoxymethy)cyclobutyl]guanine (2f) or 2,3-bis(hydroxymethy)-1-cyclobutanol (7b)- Carbocyclic oxetanocin analogues (A, 1d; G, 2d) and related compounds inclusing 4b were assayed against a broad variety of viruses. It apperred that the activity of 2d against herpes simplex virus(HSV) and varicella-zoster virus (VZV) at least partially depends on phosphorylation by the virus-induced thymidine kinase (TK). Although 1d and 2d are inhibitory to the replication of human immunodeficiency virus (HIV), they are quite toxic to proliferating human T-lymphocytes.

• 社団法人日本薬学会の論文
• 1993-03-15

著者

• 佐藤 美洋

  北海道大学大学院薬学研究院

• 佐藤 佳子

  Department Of Pharmaceutical Sciences Tokushima Bunri University

• Sato Y

  Osaka Prefecture University

• De Clercq

  Rega Inst. For Medical Res. Katholieke Universiteit Leuven

• 丸山 徳見

  Department of Pharmaceutical Sciences, Tokushima Bunri University

• 花井 泰明

  Department of Pharmaceutical Sciences, Tokushima Bunri University

• SNOECK Robert

  Rega Institute for Medical Research, Katholieke Universiteit Leuven

• ANDREI Graciela

  Rega Institute for Medical Research, Katholieke Universiteit Leuven

• HOSOYA Mitsuaki

  Rega Institute for Medical Research, Katholieke Universiteit Leuven

• BALZARINI Jan

  Rega Institute for Medical Research, Katholieke Universiteit Leuven

• De Clercq

  Rega Institute For Medical Research Katholieke Universiteit Leuven

• Snoeck Robert

  Rega Institute For Medical Research Katholieke Universiteit Leuven

• Balzarini Jan

  Rega Institute For Medical Research Katholieke Universiteit Leuven

• Sato Y

  (present Address)tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• 丸山 徳見

  徳島文理大 薬

• Hosoya Mitsuaki

  Rega Institute For Medical Research Katholieke Universiteit Leuven

• Andrei Graciela

  Rega Institute For Medical Research Katholieke Universiteit Leuven

• 佐藤 嘉信

  Department Of Chemical Engineering University Of Osaka Prefecture

• 丸山 徳見

  Department Of Pharmaceutical Sciences Tokushima Bunri University

• Balzarini Jan

  Rega Inst. For Medical Res.

• 花井 泰明

  Department Of Pharmaceutical Sciences Tokushima Bunri University

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