Synthesis and Antiviral Activity Evaluation of some Novel Acyclic C-Nucleosides
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概要
- 論文の詳細を見る
The preparation of novel 5-amino or 7-hydroxy substituted pyrazolo[4,3-b]pyridine and pyrazolo[3,4-c]pyridine acyclic C-nucleosides is described. Their synthesis was carried out by condensation of suitably substituted lithiated picolines with 2-benzyloxyethoxymethylchloride followed by pyrazole ring annulation. The compounds were evaluated for their antiviral activity against a wide panel of viruses, but were found inactive at subtoxic concentrations.
- 公益社団法人日本薬学会の論文
- 2008-06-01
著者
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Balzarini Jan
Rega Inst. For Medical Res.
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Marakos Panagiotis
Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens
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Marakos Panagiotis
Department Of Pharmacy Division Of Pharmaceutical Chemistry University Of Athens
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LOUGIAKIS Nikolaos
Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens
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POUL Nicole
Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens
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Poul Nicole
Department Of Pharmacy Division Of Pharmaceutical Chemistry University Of Athens
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Lougiakis Nikolaos
Department Of Pharmacy Division Of Pharmaceutical Chemistry University Of Athens
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Lougiakis Nikolas
Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens
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