Synthesis and Antiviral and Antineoplastic Activities of Some Novel Carbocyclic Guanosine Analogues with a Cyclobutane Ring
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概要
- 論文の詳細を見る
Cyclobutyl nucleoside analogues containing guanine and 8-azaguanine (compounds 5-10) were perpared from (1R, cis)-3-aminomethyl-2,2-dimethylcyclobutylmethanol (1). All were evaluated as anitviral and antitumoral agents in a variety of assay systems. Compounds 6 and 7 showed a noteworthy activity against a respiratory syncytial virus and compound 10 was moderately active against vaccinia virus. Only compound 5 showed some cytostatic activity.
- 公益社団法人日本薬学会の論文
- 1999-09-15
著者
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De Clercq
Rega Inst. For Medical Res. Katholieke Universiteit Leuven
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BALZARINI Jan
Rega Institute for Medical Research, Katholieke Universiteit Leuven
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Blanco Jose
Departamento De Farmacologia Facultade De Farmacia Universidade De Santiago De Compostela
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De Clercq
Rega Institute For Medical Research Katholieke Universiteit Leuven
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Fernandez F
Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela
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Rodriguez-borges Jose
Ciq. Departamento De Quimica Da Facultade De Ciencias Do Porto
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Hergueta Antonio
Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela
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Balzarini J
Rega Inst. For Medical Res.
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Balzarini Jan
Rega Institute For Medical Research Katholieke Universiteit
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FERNANDEZ Franco
Departmento de Quimica Organica, Facultad de Farmacia, Universidad de Santiago
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LOPEZ Carmen
Departmento de Quimica Organica, Facultad de Farmacia, Universidad de Santiago
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Lopez Carmen
Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela
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Balzarini Jan
Rega Inst. For Medical Res.
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Balzarini J
Rega Institute For Medical Research Katholieke Universiteit Leuven
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CAAMANO Olga
Departamento de Quimica Organica, Facultade de Farmacia, Universidade de Santiago de Compostela
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GARCIA-MERA Xerardo
Departmento de Quimica Organica, Facultade de Farmacia, Universidade de Santiago
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RODRIGUEZ-BORGES Jose
Departmento de Quimica Organica, Facultade de Farmacia, Universidade de Santiago
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Caamano Olga
Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela
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Garcia-mera Xerardo
Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela
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Brea Jose
Departamento De Farmacologia Facultade De Farmacia Universidade De Santiago De Compostela
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Fernandez Franco
Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago
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