Novel Carbocyclic Nucleosides Containing a Cyclobutyl Ring : Adenosine Analogues

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概要

• 論文の詳細を見る

• (1s, 1'R)-cis-1-(3'-aminomethyl-2', 2'-dimethylcyclobutyl)ethanol (1) and (1S, 1'R)-cis-1-[3'-(2-aminoethyl)2', 2'-diniethylcyclobutyl]ethanol (2) were used as precursors in the synthesis of cyclobutyl nucleoside analogues containing adenine and 8-azaadenine moieties, which were tested as antiviral and antitumoral agents in a variety of assay systems. Compounds 8 and 9 displayed significant activity against respiratory syncytial virus, and compounds 14 and 15 were moderately active against vaccinia virus.

• 公益社団法人日本薬学会の論文
• 2001-09-01

著者

• BALZARINI Jan

  Rega Institute for Medical Research, Katholieke Universiteit Leuven

• Blanco Jose

  Departamento De Farmacologia Facultade De Farmacia Universidade De Santiago De Compostela

• Fernandez F

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• Hergueta Antonio

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• Balzarini J

  Rega Inst. For Medical Res.

• Balzarini Jan

  Rega Institute For Medical Research Katholieke Universiteit

• FERNANDEZ Franco

  Departmento de Quimica Organica, Facultad de Farmacia, Universidad de Santiago

• LOPEZ Carmen

  Departmento de Quimica Organica, Facultad de Farmacia, Universidad de Santiago

• CLERCQ Eric

  Rega Institute for Medical Research, Katholieke Universiteit

• Lopez Carmen

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• Clercq E

  Rega Institute For Medical Research Katholieke Universiteit

• Clercq Eric

  Rega Institute For Medical Research Katholieke Universiteit Leuven

• Balzarini Jan

  Rega Inst. For Medical Res.

• Balzarini J

  Rega Institute For Medical Research Katholieke Universiteit Leuven

• Brea Jose

  Departamento De Farmacologia Facultade De Farmacia Universidade De Santiago De Compostela

• Fernandez Franco

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago

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