Synthesis of Novel Purinyl-1'-homocarbanucleosides Based on a Cyclopenta[b]pyrazine System

スポンサーリンク

概要

• 論文の詳細を見る

• cis-2,3-Diphenyl-6,7-dihydro-5H-cyclopenta[b]pyrazine-5,7-dimethanol, prepared by Diels-Alder reaction from cyclopentadiene and appropriately protected 2-imidazolone-followed by dihydroxylation, glycol protection, diamine deprotection, condensation with benzyl, glycol deprotection, oxidative cleavage and reduction-, was used to synthesize (±)-cis-{[7-(6-chloro-9H-purin-9-yl)methyl]-2,3-diphenyl-6,7-dihydro-5H-cyclopenta[b]pyrazin-5-yl}methanol, a key intermediate for novel 1'-homocarbanucleosides based on a cyclopenta[b]pyrazine scaffold as shown by its conversion into several 6-substituted purinyl derivatives.

• 公益社団法人日本薬学会の論文
• 2008-05-01

著者

• Fernandez F

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• Rodriguez-borges Jose

  Ciq. Departamento De Quimica Da Facultade De Ciencias Do Porto

• FERNANDEZ Franco

  Departmento de Quimica Organica, Facultad de Farmacia, Universidad de Santiago

• LOPEZ Carmen

  Departmento de Quimica Organica, Facultad de Farmacia, Universidad de Santiago

• Lopez Carmen

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• CAAMANO Olga

  Departamento de Quimica Organica, Facultade de Farmacia, Universidade de Santiago de Compostela

• GARCIA-MERA Xerardo

  Departmento de Quimica Organica, Facultade de Farmacia, Universidade de Santiago

• Caamano Olga

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• Garcia-mera Xerardo

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• BALO Carmen

  Departamento de Quimica Organica, Facultade de Farmacia, Universidade de Santiago de Compostela

• Balo Carmen

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• Fernandez Franco

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago

関連論文

• Novel Carbocyclic Nucleosides Containing a Cyclobutyl Ring : Adenosine Analogues
• Carbocyclic Analogues of Nucleosides from bis-(Hydroxymethyl)-cyclopentane: Synthesis, Antiviral and Cytostatic Activities of Adenosine, Inosine and Uridine Analogues
• Synthesis and Antiviral and Antineoplastic Activities of Some Novel Carbocyclic Guanosine Analogues with a Cyclobutane Ring
• Synthesis of Novel Purinyl-1'-homocarbanucleosides Based on a Cyclopenta[b]pyrazine System
• New Hexahydrocarbazoles and Spiro Indoles, and Their Affinity for D_2 Dopamine and 5-HT_ Serotonin Receptors
• Synthesis and Evaluation of Adenosine Antagonist Activity of a Series of [1,2,4] Triazolo [1,5-c] quinazolines
• Synthesis of Series of 1- and 3-Differently Substituted Xanthines from Imidazoles
• Novel Carbocyclic Nucleoside Containing a Cyclopentyl Ring and Uracil
• On the Charge Asymmetry Effects in the ^3He(^3H,d) ^4He Reaction

スポンサーリンク