Carbocyclic Analogues of Nucleosides from bis-(Hydroxymethyl)-cyclopentane: Synthesis, Antiviral and Cytostatic Activities of Adenosine, Inosine and Uridine Analogues

スポンサーリンク

概要

• 論文の詳細を見る

• Six new carbocyclic nucleosides were prepared by constructing a purine base (in compounds 9-11) or pyrimidine base (in 6-8) on the amino groups of (±)-(1β, 2α, 4β)-4-amino-1, 2-cyclopentanedimethanol (4) and (±)-(1β, 3α, 4β)-4-amino-1, 3-cyclopentanedimethanol (5), and their activities against a variety of viruses and tumour cell lines were determined.

• 公益社団法人日本薬学会の論文
• 2003-09-01

著者

• De Clercq

  Rega Inst. For Medical Res. Katholieke Universiteit Leuven

• BALZARINI Jan

  Rega Institute for Medical Research, Katholieke Universiteit Leuven

• Blanco Jose

  Departamento De Farmacologia Facultade De Farmacia Universidade De Santiago De Compostela

• De Clercq

  Rega Institute For Medical Research Katholieke Universiteit Leuven

• Fernandez F

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• Rodriguez-borges Jose

  Ciq. Departamento De Quimica Da Facultade De Ciencias Do Porto

• Balzarini J

  Rega Inst. For Medical Res.

• Balzarini Jan

  Rega Institute For Medical Research Katholieke Universiteit

• FERNANDEZ Franco

  Departmento de Quimica Organica, Facultad de Farmacia, Universidad de Santiago

• Balzarini Jan

  Rega Inst. For Medical Res.

• Balzarini J

  Rega Institute For Medical Research Katholieke Universiteit Leuven

• CAAMANO Olga

  Departamento de Quimica Organica, Facultade de Farmacia, Universidade de Santiago de Compostela

• RODRIGUEZ-BORGES Jose

  CIQ, Departamento de Quimica, Facultade de Ciencias do Porto

• Caamano Olga

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• Brea Jose

  Departamento De Farmacologia Facultade De Farmacia Universidade De Santiago De Compostela

• Fernandez Franco

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago

関連論文

• Synthesis, Antiviral, Antibacterial and Antitumor Cell Activities of 2'-Deoxy-2'-fluoropuromycin
• Synthesis and Antiviral Activity of Carbocyclic Oxetanocin Analogues(C-OXT-A, C-OXT-G) and Related Compounds. II
• Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors: Part I. Synthesis and Structure-Activity Relationship of 1-Alkoxymethyl-5-alkyl-6-naphthylmethyl Uracils as HEPT Analogues
• 3-Benzamido, Ureido and Thioureidoimidazo[1, 2-a]pyridine Derivatives as Potential Antiviral Agents
• New Neplanocin Anallogues. VIII. Synthesis and Biological Activity of 6'-C-Ethyl, -Ethenyl, and -Ethynyl Derivatives of Neplanocin A
• Synthesis and Biological Evaluation of Phosphonopyrimidine and Phosphonopurine Ribonucleosides(Medeicinal Chemistry,Chemical)
• Novel Carbocyclic Nucleosides Containing a Cyclobutyl Ring : Adenosine Analogues
• Synthesis and Anti-HIV-1 and Anti-HCMV Activity of 1-Substituted 3-(3,5-Dimethylbenzyl) uracil Derivatives
• Carbocyclic Analogues of Nucleosides from bis-(Hydroxymethyl)-cyclopentane: Synthesis, Antiviral and Cytostatic Activities of Adenosine, Inosine and Uridine Analogues
• Synthesis and Antiviral and Antineoplastic Activities of Some Novel Carbocyclic Guanosine Analogues with a Cyclobutane Ring
• Synthesis of Novel Purinyl-1'-homocarbanucleosides Based on a Cyclopenta[b]pyrazine System
• New Hexahydrocarbazoles and Spiro Indoles, and Their Affinity for D_2 Dopamine and 5-HT_ Serotonin Receptors
• Synthesis and Evaluation of Adenosine Antagonist Activity of a Series of [1,2,4] Triazolo [1,5-c] quinazolines
• Synthesis of Series of 1- and 3-Differently Substituted Xanthines from Imidazoles
• Design, Synthesis, Conformational Analysis and Biological Activities of Purine-Based 1,2-Di-substituted Carbocyclic Nucleosides
• Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors, Part 7. Synthesis, Antiviral Activity, and 3D-QSAR Investigations of Novel 6-(1-Naphthoyl) HEPT Analogues
• Nonnucleoside HIV-1 Reverse-Transcriptase Inhibitors, Part 5. : Synthesis and Anti-HIV-1 Activity of Novel 6-Naphthylthio HEPT Analogues
• Partial purification and characterization of mitochondrial DNA polymerase from Plasmodium falciparum
• Novel Carbocyclic Nucleoside Containing a Cyclopentyl Ring and Uracil
• On the Charge Asymmetry Effects in the ^3He(^3H,d) ^4He Reaction
• Synthesis and Antiviral Activity Evaluation of some Novel Acyclic C-Nucleosides
• Collinone, a New Recombinant Angular Polyketide Antibiotic Made by an Engineered Streptomyces Strain
• Modification of the antibiotic olivomycin I at the 2'-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity

もっと見る 閉じる

スポンサーリンク