Design, Synthesis, Conformational Analysis and Biological Activities of Purine-Based 1,2-Di-substituted Carbocyclic Nucleosides
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概要
- 論文の詳細を見る
New 1,2-di-substituted carbocyclic nucleosides with 6-chloropurine, adenine and hypoxanthine bases were synthesized by construction of purine on the primary amino group of (±)-trans-2-aminocyclopentylmethanol. AM1 calculations showed close correspondence between the positions of the heteroatoms in the adenine derivative and dideoxyadenosine. The most active of the new compounds in antiviral assays and antitumoral assays against L1210/0,MOLT4/C8 and CEM/0 cells was the 6-chloropurine derivative.
- 公益社団法人日本薬学会の論文
- 2000-02-01
著者
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De Clercq
Rega Inst. For Medical Res. Katholieke Universiteit Leuven
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TEIJEIRA Marta
Departamento de Quimica Organica, Facultad de Quimica, Universidad de Vigo
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TERAN Carmen
Departamento de Quimica Organica, Facultad de Quimica, Universidad de Vigo
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De Clercq
Rega Institute For Medical Research Katholieke Universiteit Leuven
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Teran Carmen
Departamento De Quimica Organica Facultad De Quimica Universidad De Vigo
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Teijeira Marta
Departamento De Quimica Organica Facultad De Quimica Universidad De Vigo
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Uriarte Eugenio
Departamento De Quimica Organica Facultad De Farmacia Universidad De Santiago De Compostela
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Santana Lourdes
Laboratiorio De Quimica Farmaceutica Facultad De Farmacia Universidad De Santiago De Compostela
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TEIJEIRA Marta
Laboratiorio de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Santiago de Compostela
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URIARTE Eugenio
Laboratiorio de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Santiago de Compostela
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