Synthesis and Evaluation of Adenosine Antagonist Activity of a Series of [1,2,4] Triazolo [1,5-c] quinazolines

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概要

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• A series of [1, 2, 4] triazolo [1, 5-c] quinazolines were prepared in satisfactory yields by reaction of some derivatives of 2-aminobenzohydrazide with several hydrochlorides of aromatic amidines, and their binding affinities for the recombinant human adenosine A_<2A> and A_<2B> receptors were determined. None of the new compounds showed noteworthy affinity for these receptors, though a very high affinity for the A_<2A> receptor and, consequently, a high level of A_<2A>/A_<2B> selectivity was revealed for one of the synthesized compounds.

• 公益社団法人日本薬学会の論文
• 2007-03-01

著者

• Blanco Jose

  Departamento De Farmacologia Facultade De Farmacia Universidade De Santiago De Compostela

• Fernandez F

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• Balzarini J

  Rega Inst. For Medical Res.

• FERNANDEZ Franco

  Departmento de Quimica Organica, Facultad de Farmacia, Universidad de Santiago

• LOPEZ Carmen

  Departmento de Quimica Organica, Facultad de Farmacia, Universidad de Santiago

• Lopez Carmen

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• Balzarini J

  Rega Institute For Medical Research Katholieke Universiteit Leuven

• CAAMANO Olga

  Departamento de Quimica Organica, Facultade de Farmacia, Universidade de Santiago de Compostela

• Caamano Olga

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• BALO Carmen

  Departamento de Quimica Organica, Facultade de Farmacia, Universidade de Santiago de Compostela

• BREA Jose

  Departamento de Farmacologia, Facultade de Farmacia, Universidade de Santiago de Compostela

• Brea Jose

  Departamento De Farmacologia Facultade De Farmacia Universidade De Santiago De Compostela

• Balo Carmen

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago De Compostela

• Fernandez Franco

  Departamento De Quimica Organica Facultade De Farmacia Universidade De Santiago

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