SYNTHESIS OF THE CARBOCYCLIC ANALOGUE OF OXETANOCIN A

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概要

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• 2,3-Bis(benzoyloxymethyl)cyclobutanone (3__〜) was prepared in three steps from diethyl 3,3-diethoxy-1,2-cyclobutanedicarboxylate (1__〜). Hydrogenation of the oxime (4__〜) of 3__〜 provided the two amino compounds (<5a>___〜 and <5b>___〜), from which 9-[2,3-bis(hydroxymethyl)cyclobuthyl]adenines (<9a>___〜 and <9b>___〜) were synthesized in four steps. The steric configurations of 3__〜, <5a>___〜, <5b>___〜, <9a>___〜 and <9b>___〜 were established by ^1H-NMR spectroscopies including the NOE difference experiments.

• 社団法人日本薬学会の論文
• 1989-05-25

著者

• 丸山 徳見

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• 佐藤 佳子

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• 堀井 尚彦

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• 本庄 美喜男

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• 佐藤 佳子

  Department Of Pharmaceutical Sciences Tokushima Bunri University

• 本庄 美喜男

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• 丸山 徳見

  徳島文理大 薬

• Sato Yoshiko

  Department Of Pharmaceutical Sciences Tokushima Bunri University

• 堀井 尚彦

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• 丸山 徳見

  Faculty of Pharmaceutical Sciences, Osaka University

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