Halogenium-Induced Cyclization of 5-Substituted 6,2'-O-Cyclouridine
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概要
- 論文の詳細を見る
Reaction of 5-chloro (or bromo)-6,2'-O-cyclouridine (IIa or IIb) with N-bromo(or chloro)-succinimide gave 5-bromo-5-chloro-5,6-dihydro-6,2' : 6,5'-di-O-cyclouridine (VI). A similar reaction of 5-nitro-6,2'-O-cyclouridine (VII) afforded the 5-chloro(or bromo)-5-nitro analog (VIII or IX). Both VI and VIII were mixtures of two diastereoisomers and each isomeric mixture was separated by preparative high-performance liquid chromatography. The steric configurations and mass spectra of VI, VIII and IX are discussed.
- 社団法人日本薬学会の論文
- 1986-09-25
著者
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木村 修平
School Of Pharmacy Tokushima Bunri University
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佐藤 佳子
Department Of Pharmaceutical Sciences Tokushima Bunri University
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丸山 徳見
School of Pharmacy, Tokushima Bunri University
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佐藤 佳子
School of Pharmacy, Tokushima Bunri University
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本庄 美喜男
School of Pharmacy, Tokushima Bunri University
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本庄 美喜男
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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丸山 徳見
徳島文理大 薬
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Sato Yoshiko
Department Of Pharmaceutical Sciences Tokushima Bunri University
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