A Novel Method for the Synthesis of Purine Nucleosides using Friedel-Crafts Catalysts
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概要
- 論文の詳細を見る
9-β-D-Ribofuranosyladenine was synthesized by condensation of N^6-octanoyladenine (I) with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (II) or 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose (III) in sym-dichloroethane or chlorobenzene in the presence of Friedel-Crafts catalysts followed by hydrolysis of the acyl groups. By this procedure the formation of the corresponding anomer was not observed Similarly, 9-β-D-ribopyranosyladenine was synthesized from I and 1,2,3,4-tetra-O-acetyl-β-D-ribopyranose, and 9-β-D-ribofuranosylguanine in high yield from N^2-palmitoylguanine and III.
- 公益社団法人日本薬学会の論文
- 1968-06-25
著者
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古川 純康
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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本庄 美喜男
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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本庄 美喜男
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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古川 純康
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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