Syntheses of N^4,2', 3', 5'-Tetraacylcytidines from N^4-Acylcytosines, via Condensation with Tetraacylribose and Transribosylation with Acylated Purine Nucleosides
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概要
- 論文の詳細を見る
N^4-Isobutyryl- and -(2-ethylhexanoyl)cytosines (Ia, b) were synthesized by acylation of cytosine. N^4,2', 3', 5'-Tetraacylcytidines (III) were synthesized by two methods involving stannic chloride catalysis. One involeves condensation of N^4-acylcytosines (I) and 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (II), and the other involves transribosylation between N^4-acylcytosines and acyl-inosines or -guanosines (IVa-d). N^4-Octanoyl-2', 3', 5'-triacetylcytidine (IIIf) waS converted into cytidine by deacylation in a good yield.
- 公益社団法人日本薬学会の論文
- 1988-09-25
著者
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古川 純康
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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古川 純康
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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杉浦 義弘
Chemistry Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.,
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古矢 修一
Chemistry Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.,
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杉浦 義弘
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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古矢 修一
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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