The Nephritogenic Glycopeptide from Rat Glomerular Basement Membrane. II. Synthesis of O-(α-D-glucopyranosyl)-(1→6)-O-β-D-glucopyranosyl-(1→6)-N-(L-β-aspartyl)-α-D-glucopyranosylamine (α-D-Glc-(1→6)-β-D-Glc-(1→6)-α-D-Glc-(1→Asn))

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概要

• 論文の詳細を見る

• O-(α-D-Glucopyranosyl)-(1→6)-O-β-D-glucopyranosyl-(1→6)-N-(L-β-aspartyl)-α-D-glucopyranosylamine has been prepared, as a model of a derivative possibly present in the glomerular basement membrane of rats, by condensation of the corresponding trisaccharide α-amine with α-ethyl benzyloxycarbonyl-L-aspartate in the presence of diethylphosphorocyanidate. This was followed by hydrogenolysis, de-O-acetylation, and deethoxylation of the resulting trisaccharide-amino acid linked derivative to remove the protecting groups. The ^<13>C-nuclear magnetic resonance spectra of this product and related glycosylamine derivatives are analyzed and discussed.

• 公益社団法人日本薬学会の論文
• 1981-11-25

著者

• 荻原 幸夫

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 荻原 幸夫

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 竹田 忠紘

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 柴田 整一

  Clinical Research Institute National Medical Center

• 藤井 礼子

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 鈴木 恵子

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 杉浦 義弘

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 浜田 千秋

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 杉浦 義弘

  Chemistry Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.,

• Takeda T

  Kyoritsu University Of Pharmacy

• 杉浦 義弘

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 浜田 千秋

  Faculty Of Pharmaceutical Sciences Nagoya City University

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