Presence of Protein Polymorphism in Karasurin, an Abortifacient and Anti-tumor Protein, Identified with Physicochemical Properties

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概要

• 論文の詳細を見る

• Karasurin is an abortifacient plant protein isolated from fresh root tubers of Trichosanthes kirilowii MAXIMOWICZ var. japonicum KITAMURA (Cucurbitaceae). This study describes the presence of protein polymorphism in karasurin (karasurin-A and karasurin-B) separated by ion-exchange chromatography. Two components showed no differences in the molecular weight (ca. 28000), the amino acid composition, the neutral sugar content and part of the amino acid sequence. A unique difference was observed in their isoelectric points (10.1 for karasurin-A and 10.2 for karasurin-B). However, modifications of glycosylation or phosphorylation were not found. Biological assays for inducing mid-term abortion in pregnant mice and inhibition of the growth of BeWo cells gave no significant differences between them. The presence of protein polymorphism in karasurin, whose biological significance is not yet understood, is a first finding among several abortifacient proteins.

• 公益社団法人日本薬学会の論文
• 1991-08-25

著者

• 荻原 幸夫

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 若林 克己

  Hormone Assay Center Institute Of Endocrinology Gunma University

• 荻原 幸夫

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 竹田 忠紘

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 加藤 幸雄

  Hormone Assay Center Institute Of Endocrinology Gunma University

• 豊川 峻輔

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 豊川 峻輔

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Takeda T

  Kyoritsu University Of Pharmacy

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