Effects of Saikosaponin Metabolites on the Hemolysis of Red Blood Cells and Their Adsorbability on the Cell Membrane

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概要

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• The hemolytic properties and the adsorbability on red blood cells of saikosaponin a, saikosaponin d and 13 metabolites formed in the alimentary tract were investigated. Among these compounds, saikosaponin d and its intestinal product, prosaikogenin G, which possess an α-hydroxyl function at C16,showed the strongest hemolytic activity at the dose range of 1.0 to 5.0 μg/ml. Saikosaponin a and its intestinal product, prosaikogenin F, which possess a β-hydroxyl function at C16,showed activity above 10 μg/ml. In this case, the monoglycoside, prosaikogenin F, showed the stronger activity than the diglycoside, saikosaponin a. Among the gastric products whose ether ring was cleaved to produce a carbinol, the monoglycosides, prosaikogenin A and prosaikogenin H, showed a slight activity above 25 μg/ml, and the saikogenins except saikogenin A were inactive. Saikogenin A, however, had hemolytic activity at a dose of 15 μg/ml. The adsorbabilities of these compounds on red blood cell membranes closely paralleled their degrees of hemolytic activity.

• 公益社団法人日本薬学会の論文
• 1989-12-25

著者

• 荻原 幸夫

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 荻原 幸夫

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 雨谷 栄

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 能勢 充彦

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 能勢 充彦

  名古屋市立大学大学院薬学研究科生薬学分野

• 雨谷 栄

  Faculty Of Pharmaceutical Sciences Nagoya City University

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