Peptides in Higher Plants. II. The Crystal Structure of Tri-N-methylfrangulanine Methiodide

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概要

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• The crystal structure of tri-N-methylfrangulanine methiodide, C_<32>H_<54>O_4N_4I has been determined in order to clarify the conformation and absolute configuration of frangulanine, C_<28>H_<44>O_4N_4,a peptide alkaloid isolated from Hovenia dulcis. The crystals are orthorhombic with space group P2_12_12_1 and unit cell dimensions are a=8.826 (8), b=49.95 (2), c=8.296 (8) A, Z=4. The crystal structure was solved by the heavy-atom method and refined by the block-diagonal least-squares method including anisotropic thermal parameters. The final R value for 1383 observed structure factors was 0.10. The absolute configuration was determined by the use of the anomalous dispersion of iodine atom for Cu Kα radiation. Frangulanine is composed of all L-amino acids and the conformation of the peptide units is of the β-pleated sheets structure.

• 公益社団法人日本薬学会の論文
• 1976-09-25

著者

• 柴田 承二

  Shibata Laboratory of Natural Medicinal Materials

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 柴田 承二

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 荻原 幸夫

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 荻原 幸夫

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 柴田 承二

  Shibata Laboratory Of Natural Medicinal Materials C

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 飯高 洋一

  西東京科学大学理工学部

• 柴田 承二

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

• 高井 誠

  Technical R And D Division Terumo Co. Ltd.

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