Antitumorigenic Activities of Chalcones. I. Inhibitory Effects of Chalcone Derivatives on ^<32>Pi-Incorporation into Phospholipids of HeLa Cells Promoted by 12-O-Tetradecanoyl-phorbol 13-Acetate (TPA)
スポンサーリンク
概要
- 論文の詳細を見る
More than forty chalcone derivatives were synthesized to examine their structure-activity relationship against tumorigenesis. As a primary screening test, the inhibitory activities of the chalcones for the ^<32>Pi-incorporation into phospholipids of HeLa cells enhanced by 12-O-tetradecanoyl-phorbol 13-acetate (TPA) were examined. 3-Hydroxy-chalcone derivatives possessing methyl group in 3'-, 4'-, or 2'-position and isoliquiritigenin homologs showed potent inhibitory activities in the phosphorylation test, which suggests their antitumorigenic effects.
- 社団法人日本薬学会の論文
- 1995-12-15
著者
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岩田 進
Research Laboratory, Minophagen Pharmaceutical Co.,
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柴田 承二
Shibata Laboratory of Natural Medicinal Materials
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岩田 進
Research Laboratory Minophagen Pharmaceutical Co.
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永田 信幸
Research Laboratory, Minophagen Pharmaceutical Co.,
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西野 輔翼
京都府立医科大学 院 分子生化学
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西野 剛史
Research Laboratory, Minophagen Pharmaceutical Co.
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里見 佳子
National Cancer Center Research Institute
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西野 輔翼
National Cancer Center Research Institute
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柴田 承二
Shibata Laboratory Of Natural Medicinal Materials C
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永田 信幸
ミノファーゲン製薬
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Nagata Nobuyuki
Research Laboratory Minophagen Pharmaceutical Co.
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Nagata Nobuyuki
Research Laboratory Minophagen Co.
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里見 佳子
京都府立医科大学 院 分子生化学
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西野 剛史
Research Laboratory Minophagen Pharmaceutical Co.
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Shibata Shoji
Shibata Laboratory Of Natural Medicinal Materials C/o Minophagen Pharmaceutical Co.
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Iwata Susumu
Research Laboratory Minophagen Pharmaceutical Co.
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Satomi Yoshiko
National Cancer Center Research Institute
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永田 信幸
Research Laboratory Minophagen Pharmaceutical Co.
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