Chetracin A and Chaetocins B and C, Three New Epipolythiodioxo-piperazines from Chaetomium spp.

元データ 1988-06-25 社団法人日本薬学会


A new dimeric epipolythiodioxopiperazine named chetracin A with two tetrasulfide bridges was isolated from Chaetomium nigricolor and C. retardatum, and the structure (3) proposed chiefly from proton and carbon-13 nuclear magnetic resonance (^1H-and ^<13>C-NMR) data was established by X-ray analysis. Two congeners of chaetocin (2) named chaetocins B and C were isolated from C. virescens var. thielabioideum, and were proved tobe homologs with one disulfide and one trisulfide bridge (9) and with two trisulfide bridges (10), respectively, from spectral data, chiefly NMR and fast atom bombardment mass spectrometry/mass spectrometry (FAB MS/MS). The structure-activity relationships observed for the antibacterial activity and cytotoxicity of the related compounds are discussed.


飯高 洋一 Nishi-tokyo Science University
飯高 洋一 Faculty of Pharmaceutical Sciences, The University of Tokyo
木下 武 Analytical and Metabolic Research Laboratories
鈴木 康司 Meiji College Of Pharmacy
小山 清隆 Meiji College of Pharmacy
名取 信策 Meiji College of Pharmacy
木下 武 Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
斎藤 隆夫 Meiji College of Pharmacy
飯高 洋一 School Of Medicine Teikyo University
飯高 洋一 Faculty Of Pharmaceutical Sciences University Of Tokyo
飯高 洋一 西東京科学大学理工学部
飯高 洋一 Faculty Of Pharmaceutical Sciences The University Of Tokyo