Chetracin A and Chaetocins B and C, Three New Epipolythiodioxo-piperazines from Chaetomium spp.

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概要

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• A new dimeric epipolythiodioxopiperazine named chetracin A with two tetrasulfide bridges was isolated from Chaetomium nigricolor and C. retardatum, and the structure (3) proposed chiefly from proton and carbon-13 nuclear magnetic resonance (^1H-and ^<13>C-NMR) data was established by X-ray analysis. Two congeners of chaetocin (2) named chaetocins B and C were isolated from C. virescens var. thielabioideum, and were proved tobe homologs with one disulfide and one trisulfide bridge (9) and with two trisulfide bridges (10), respectively, from spectral data, chiefly NMR and fast atom bombardment mass spectrometry/mass spectrometry (FAB MS/MS). The structure-activity relationships observed for the antibacterial activity and cytotoxicity of the related compounds are discussed.

• 社団法人日本薬学会の論文
• 1988-06-25

著者

• 飯高 洋一

  Nishi-tokyo Science University

• 飯高 洋一

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 木下 武

  Analytical and Metabolic Research Laboratories

• 鈴木 康司

  Meiji College Of Pharmacy

• 小山 清隆

  Meiji College of Pharmacy

• 名取 信策

  Meiji College of Pharmacy

• 木下 武

  Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.

• 斎藤 隆夫

  Meiji College of Pharmacy

• 飯高 洋一

  School Of Medicine Teikyo University

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 飯高 洋一

  西東京科学大学理工学部

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

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