REACTION OF ORGANOMETALLIC REAGENTS WITH 2'- AND 3'-KETOURIDINE DERIVATIVES : SYNTHESIS OF URACIL NUCLEOSIDES BRANCHED AT THE 2'- AND 3'-POSITIONS(Communications to the Editor)

元データ 1987-06-25 社団法人日本薬学会

概要

The reaction of organolithium, Grignard, and organoaluminum reagents with 2'- and 3'-ketouridine derivatives was examined. For the reaction of 2',5'-bis-O-(tert-butyldimethylsilylj-3'-ketouridine, both organolithiums and organoaluminums seem to be practically useful. But only organoaluminums gave satisfactory yields in the reaction of 3',5'-O-(tetraisopropyldisiloxan-1, 3-divl)-2'-ketouridine.

著者

田中 博道 School of Pharmaceutical Sciences, Showa University
宮坂 貞 School of Pharmaceutical Sciences, Showa University
山口 健太郎 千葉大学分析センター
山口 健太郎 School of Pharmaceutical Sciences, Showa University
飯高 洋一 Faculty of Pharmaceutical Sciences, The University of Tokyo
山口 健太郎 School Of Pharmaceutical Sciences Showa University
宮坂 貞 昭和大学大学院薬学研究科医療薬学専攻
早川 弘之 School of Pharmaceutical Sciences, Showa University
伊藤 直子 School of Pharmaceutical Sciences, Showa University
中島 政子 School of Pharmaceutical Sciences, Showa University
中島 政子 School Of Pharmaceutical Sciences Showa University
宮坂 貞 School Of Pharmaceutical Sciences Showa University
飯高 洋一 Faculty Of Pharmaceutical Sciences The University Of Tokyo
伊藤 直子 School Of Pharmaceutical Sciences Showa University

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