PALLADIUM-CATALYZED CROSS-COUPLING OF 2-IODOADENOSINE WITH TERMINAL ALKYNES : SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 2-ALKYNYLADENOSINES

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概要

• 論文の詳細を見る

• Reaction of 2-iodoadenosine (2) with terminal alkynes in the presence of bis (triphenylphosphine) palladium dichloride and cuprous iodide in triethylamine and N, N, -dimethylformamide gave 2-alkynyl-adenosines (3a-h) in excellent yields. Several compounds showed high activity as inhibitors in rat passive cutaneous anaphylaxis (PCA) reaction. Among them, 2-(3-hydroxypropynyl)- and 2-(3-hydroxybutynyl)-adenosines (3d, f) are much more potent than disodium cromoglycate (DSCG).

• 公益社団法人日本薬学会の論文
• 1985-04-25

著者

• 宮坂 貞

  School of Pharmaceutical Sciences, Showa University

• 町田 治彦

  Research Laboratories Yamasa Shoyu Co. Ltd.

• 松田 彰

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 宮坂 貞

  昭和大学大学院薬学研究科医療薬学専攻

• 宮坂 貞

  School Of Pharmaceutical Sciences Showa University

• 松田 彰

  School of Pharmaceutical Sciences, Showa University

• 篠崎 操

  School of Pharmaceutical Sciences, Showa University

• 畔蒜 藤一

  Research Laboratories, Yamasa Shoyu Co., Ltd.

• 畔蒜 藤一

  Research Laboratories Yamasa Shoyu Co. Ltd.

• 篠崎 操

  School Of Pharmaceutical Sciences Showa University

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