PALLADIUM-CATALYZED CROSS-COUPLING OF 2-IODOADENOSINE WITH TERMINAL ALKYNES : SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 2-ALKYNYLADENOSINES
スポンサーリンク
概要
- 論文の詳細を見る
Reaction of 2-iodoadenosine (2) with terminal alkynes in the presence of bis (triphenylphosphine) palladium dichloride and cuprous iodide in triethylamine and N, N, -dimethylformamide gave 2-alkynyl-adenosines (3a-h) in excellent yields. Several compounds showed high activity as inhibitors in rat passive cutaneous anaphylaxis (PCA) reaction. Among them, 2-(3-hydroxypropynyl)- and 2-(3-hydroxybutynyl)-adenosines (3d, f) are much more potent than disodium cromoglycate (DSCG).
- 公益社団法人日本薬学会の論文
- 1985-04-25
著者
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宮坂 貞
School of Pharmaceutical Sciences, Showa University
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町田 治彦
Research Laboratories Yamasa Shoyu Co. Ltd.
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松田 彰
Faculty Of Pharmaceutical Sciences Hokkaido University
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宮坂 貞
昭和大学大学院薬学研究科医療薬学専攻
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宮坂 貞
School Of Pharmaceutical Sciences Showa University
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松田 彰
School of Pharmaceutical Sciences, Showa University
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篠崎 操
School of Pharmaceutical Sciences, Showa University
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畔蒜 藤一
Research Laboratories, Yamasa Shoyu Co., Ltd.
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畔蒜 藤一
Research Laboratories Yamasa Shoyu Co. Ltd.
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篠崎 操
School Of Pharmaceutical Sciences Showa University
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