Alkyl Addition Reaction of Pyrimidine 2'-Ketonucleosides : Synthesis of 2'-Branched-Chain Sugar Pyrimidine Nucleosides : Nucleosides and Nucleotides. LXXXI^1
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概要
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The reaction of 4-ethoxy-1-(3,5-O-tetraisopropyldisiloxanyl-1,3-diyl-β-D-erythro-pentofuran-2-ulosyl)-2(1H)-pyrimidinone (11) with various organometallic reagents yielded corresponding 2'-branched-chain sugar pyrimidine nucleosides. Only in the reactions with MeMgBr and EtMgBr was the more hindered β-attack observed to afford and 2'-alkyl ribofuranosides (13a, b). In the reaction of 11 with MeLi, Me_3,Al, or PhMgBr, 2'-methyl or phenyl arabinosides (12a, b, c)were obtained stereoselectively. Conversion of these pyrimidine nucleosides into cytosine derivatives is also described and their antileukemic and antiviral activities are discussed.
- 社団法人日本薬学会の論文
- 1988-03-25
著者
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佐々木 琢磨
Cancer Research Institute Kanazawa University
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上田 亨
Faculty of Pharmaceutical Science, Hokkaido University
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松田 彰
Faculty Of Pharmaceutical Sciences Hokkaido University
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上田 亨
Faculty Of Pharmaceutical Sciences Hokkaido University
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松田 彰
北海道大学大学院薬学研究院
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佐々木 琢磨
金沢大 がん研
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伊藤 弘子
Faculty of Pharmaceutical Sciences, Hokkaido University
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竹貫 健二
Faculty of Pharmaceutical Sciences, Hokkaido University
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上田 亨
北海道大学薬学部
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伊藤 弘子
Faculty Of Pharmaceutical Sciences Hokkaido University
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竹貫 健二
Faculty Of Pharmaceutical Sciences Hokkaido University
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