Antitumor Polysaccharides from Some Polyporaceae, Ganoderma applanatum (PERS.) PAT and Phellinus linteus (BERK. et CURT) AOSHIMA
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概要
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Antitumor polysaccharide preparations G-Z and P-Z were fractionated from the water soluble extracts of Ganoderma applanatum (PERS.) PAT and Phellinus linteus (BERK. et CURT) AOSHIMA, basidiomycetes of Polyporaceae, respectively, by fractional precipitation with ethanol and cetyltrimethylammonium hydroxide. The structures of G-Z and P-Z consist of β-(1→3), (1→4) linked D-glucose residue, and β-(1→3) linked D-glucose residue, respectively. These polysaccharide preparations have marked antitumor activity against transplanted sarcoma 180 in mice, and a complete regression of tumors was observed in more than half of animals with no sign of toxicity. Some derivatives of P-Z were synthesized and their antitumor effects were also examined.
- 社団法人日本薬学会の論文
- 1971-04-25
著者
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佐々木 琢磨
Cancer Research Institute Kanazawa University
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池川 哲郎
National Cancer Center Research Institute
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福岡 文子
National Cancer Center Research Institute
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池川 哲郎
国立がんセ 研
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千原 呉郎
National Cancer Center Research Institute
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佐々木 琢磨
National Cancer Center Research Institute
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新井 祥子
National Cancer Center Research Institute
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新井 祥子
Faculty Of Pharmaceutical Sciences Osaka University
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池川 哲郎
国立がんセンター研究所:金沢大学教育学部
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池川 哲郎
金沢大学教育学部
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