Chemical and Biochemical Studies on Carbohydrate Esters. VI. Further Examinations on Antitumor Activities of Stearoyl Esters of Sucrose

概要

論文の詳細を見る
A series of commercially available, non-ionic surfactants produced by partial acylation of sucrose with the hydrogenated beef-tallow fatty acids, that is, the eight kinds of DK-esters containing the mono-, di-, tri-, and polyesters of stearic and palmitic acids at different ratios were tested for their antitumor effect against Ehrlich ascites carcinoma by total packed cell volume (TPCV) method. The anti-leukemia activity of these DK-esters, as well as of the sucrose-monostearate preparation (SS-C), was also examined by tissue culture method, using a mouse leukemia cell line L-5178Y. Thus, the monoester constituents contained in them proved to exert inhibiting effects against both the tumors, in spite of the negative activities of the co-existing higher esters. In addition, it has been indicated that the preparation SS-C tended to exhibit antitumor effect upon the ascites sarcoma 180 implanted in mice (TPCV method and survival method), though it showed no activity against the same tumor in solid form (so-called host-mediated bioassay).
社団法人日本薬学会の論文
1977-09-25