Chemical and Biochemical Studies on Carbohydrate Esters. VIII. Antitumor Activity of Sucrose Fatty Acid Esters

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概要

• 論文の詳細を見る

• The monoester compositions of nine new sucrose fatty acid ester preparations produced industrially, which contain mono-, di-, and polyesters of stearic and palmitic acids in different ratios, were quantitatively analyzed by gas-liquid chromatography. Monoester-rich preparations had a marked cell growth inhibiting effect upon L-5178Y, as determined by the tissue culture method. It was observed that the ID_<50> values tend to decrease with increase in HLB (hydrophile-lipophile balance) values. These preparations were effective against Ehrlich ascites carcinoma as determined by the total packed cell volume method. Preparations consisting mainly of monoesters increased the life spans of mice bearing Ehrlich ascites tumor, but were not effective against L-1210.

• 社団法人日本薬学会の論文
• 1979-09-25

著者

• 西川 嘉廣

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 池川 哲郎

  National Cancer Center Research Institute

• 矢野間 俊介

  National Cancer Center Research Institute

• 吉本 公浩

  金沢大学薬学部

• 西川 嘉廣

  金沢大学薬学部

• 西川 嘉廣

  Faculty Of Pharmaceutical Sciences Kanazawa University

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