Studies on the Water-soluble Constituents of Lichens. IV. Effect of Antitumor Lichen-glucans and Related Derivatives on the Phagocytic Activity of the Reticuloendothelial System in Mice

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Two representative preparations of antitumor lichen-polysaccharides, that is, GE-3,a partially O-acetylated pustulan-type β-D-glucan isolated from Gyrophora esculenta MIYOSHI, and UR-1-1,a lichenan-like β-D-glucan obtained from Usnea rubescens STIRT., were tested to examine their effects of the phagocytic response of the reticuloendothelial system (RES) in mice. The phagocytic activity was evaluated by measuring the vascular clearance of colloidal carbon 24 h after a single intraperitoneal administration of a test sample at a dose of 100,50,or 25 mg/kg. At the dose of 100 mg/kg, GE-3 exerted a marked RES-stimulating effect, which was comparable with that given by 50 mg/kg of zymosan : the effect appeared to decrease with decreasing dose. On the other hand, UR-1-1 failed to enhance the phagocytic activity at any of the three doses tested. In addition, it appeared that introduction of either O-lauroyl or O-carboxymethyl functions into the GE-3 molecule caused considerable loss of activity.
1981-11-25