Effect of L-Cysteine on Plasma Concentration and Urinary Excretion of 1-(Tetrahydro-2-furanyl)-5-fluorouracil Metabolites
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概要
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Effects of L-cysteine (CySH) on the plasma concentrations and the urinary excretion of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) and its metabolites were studied by high performance liquid chromatography in rats.Significantly higher plasma concentrations of FT, 5-fluorouracil (5-FU) and cis-4'-OH-FT were obtained after an oral administration of FT (500 mg/kg) combined orally with CySH (500 mg/kg) when compared to FT alone. The urinary excretions of 5-FU, trans-3'-OH-FT, cis-4'-OH-FT, trans-4'-OH-FT and 4', 5'-dehydro-FT significantly decreased up to 12 h but that of α-fluoro-β-alanine significantly increased up to 24 h by the combined administration of CySH. Furthermore, the plasma concentration of 5-FU significantly increased at 0.5 h and its urinary excretion significantly decreased up to 4 h after an intraperitoneal administration of 5-FU (10 mg/kg) combined orally with CySH (500 mg/kg) when compared to 5-FU alone. The urinary pH significantly changed to acidic and the urinary volume significantly increased by the combined administration of CySH, so it was thought that the reabsorption of 5-FU through renal tubules from urine could increase and the increment of the urinary excretion of α-fluoro-β-alanine was caused by this. Then it was suggested that the increase of the plasma concentrations of 5-FU and cis-4'-OH-FT could be attributed to the decrease of their urinary excretions after an administration of FT combined with CySH when compared to FT alone.
- 公益社団法人日本薬学会の論文
- 1991-04-25
著者
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大野 洋光
Central Research Laboratory, SS Pharmaceutical Co., Ltd.,
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中島 利章
Central Research Laboratories, SS Pharmaceutical Co., Ltd.,
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大野 洋光
Central Research Laboratory Ss Pharmaceutical Co. Ltd.
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中島 利章
Central Research Laboratory Ss Pharmaceutical Co. Ltd.
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川畑 信夫
Central Research Laboratory, SS Pharmaceutical Co., Ltd.,
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矢野 憲一
Central Research Laboratory, SS Pharmaceutical Co., Ltd.,
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矢野 憲一
Central Research Laboratory Ss Pharmaceutical Co. Ltd.
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川畑 信夫
Central Research Laboratory Ss Pharmaceutical Co. Ltd.
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