Synthesis and Antifungal Activities of a Series of (1,2-Disubstituted Vinyl)imidazoles

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概要

• 論文の詳細を見る

• A series of vinylimidazoles containing a hetero atom such as sulfur or oxygen at a β-position of the vinyl group was prepared and the antifungal activities were tested. It was found that sulfur-substituted derivatives such as (E)-1-[2-(methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole (5a-5) and (E)-1-[1-[2-(hexyloxy)phenyl]-2-(methylthio)ethenyl]-1H-imidazole (5a-6) showed exvellent antifungal activities against dermatophytes and yeast cells. The stereochemistry of the hydrochloride salt of 5a-5 was determined by X-ray crystallography. The structure-activity relationships were discussed.

• 社団法人日本薬学会の論文
• 1991-09-25

著者

• 山口 健太郎

  School of Pharmaceutical Sciences, Showa University

• 小川 正樹

  Central Research Laboratories Ss Pharmaceutical Co. Ltd.

• 山口 健太郎

  School Of Pharmaceutical Sciences Showa University

• 松田 秀明

  Central Research Laboratories, SS Pharmaceutical Co., Ltd.,

• 江藤 博通

  Central Research Laboratories, SS Pharmaceutical Co., Ltd.,

• 浅岡 健光

  Central Research Laboratories, SS Pharmaceutical Co., Ltd.,

• 倉石 忠幸

  Central Research Laboratories, SS Pharmaceutical Co., Ltd.,

• 岩佐 曜

  Central Research Laboratories, SS Pharmaceutical Co., Ltd.,

• 中島 利章

  Central Research Laboratories, SS Pharmaceutical Co., Ltd.,

• 松田 秀明

  Central Research Laboratories S S Pharmaceutical Co. Ltd.

• 松田 秀明

  エスエス製薬株式会社中央研究所

• 岩佐 曜

  エスエス製薬(株)中央研究所

• 岩佐 曜

  エスエス製薬中央研究所

• 浅岡 健光

  エスエス製薬株式会社中央研究所

• 中島 利章

  Central Research Laboratory Ss Pharmaceutical Co. Ltd.

• 倉石 忠幸

  Central Research Laboratories Ss Pharmaceutical Co. Ltd.

• 江藤 博通

  Central Research Laboratories Ss Pharmaceutical Co. Ltd.

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