Catalytic Action of Azolium Salts. II. Aroylation of 4-Chloroquinazolines with Aromatic Aldehydes Catalyzed by 1,3-Dimethylbenzimidazolium Iodide

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概要

• 論文の詳細を見る

• When a mixture of 4-chloroquinazoline (7), an aromatic aldehyde 6,sodium hydride, and a catalytic amount of 1,3-dimethylbenzimidazolium iodide (1) in tetrahydrofuran (THF) was refluxed with stirring for an appropriate time, the chlorine atom of 7 was replaced with the aroyl group, and the 4-aroylquinazolines 10 were obtained in excellent yields. Similar treatments of 4-chloro-2-methylquinazoline (8) and 4-chloro-2-phenylquinazoline (9) led to the 4-aroyl-2-methylquinazolines 11 and the 4-aroyl-2-phenylquinazolines 12,respectively.Use of N, N-dimethylformamide (DMF) instead of THF as the reaction solvent in the above reaction reduced the reaction time and increased the yields of the ketones 10 and 12 as compared with those in THF.

• 社団法人日本薬学会の論文
• 1992-01-25

著者

• 東野 武郎

  School Of Pharmaceutical Sciences University Of Shizuoka

• 飯島 千穂子

  Shizuoka College of Pharmacy

• 松田 秀明

  Central Research Laboratories, SS Pharmaceutical Co., Ltd.,

• 松田 秀明

  Central Research Laboratories S S Pharmaceutical Co. Ltd.

• 宮下 晶

  School Of Pharmaceutical Sciences University Of Shizuoka

• 飯島 千穂子

  School of Pharmaceutical Sciences, University of Shizuoka

• 飯島 千穂子

  School Of Pharmaceutical Sciences University Of Shizuoka

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