SYNTHESIS OF 2,6-DISUBSTITUTED PYRIDINES BY LITHIATION OF PYRAZOLO[1,5-a]PYRIDINES
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概要
- 論文の詳細を見る
Lithiation of 3-(4,4-dimethyl-2-oxazolin-2-yl)pyrazolo[1,5-a]pyridine (1a) with 2 molar equivalents of n-BuLi followed by reaction with benzaldehyde yielded α-(4,4-dimethyl-2-oxazolidinylidene)-6-(α-hydroxybenzyl)-2-pyridineacetonitrile (2a). Upon similar treatment of other electrophiles, the corresponding 2,6-disubstituted pyridines 2 were produced. The formation of the pyridines proceeded through lithiation, reaction with an electrophile, and ring-cleavage of the pyrazole ring.
- 社団法人日本薬学会の論文
- 1995-01-15
著者
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東野 武郎
School Of Pharmaceutical Sciences University Of Shizuoka
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丹治 健一
School of Pharmaceutical Sciences, University of Shizuoka
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宮下 晶
School Of Pharmaceutical Sciences University Of Shizuoka
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丹治 健一
School Of Food & Nutritional Sciences University Of Shizuoka
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佐藤 泰士
School of Pharmaceutical Sciences University of Shizuoka
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渡辺 小百合
School of Pharmaceutical Sciences University of Shizuoka
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